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KMID : 0903520080510030228
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Journal of the Korean Society of Agricultural Chemistry and Biotechnology
2008 Volume.51 No. 3 p.228 ~ p.232
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Induction of Glutathione S-transferase Activity by the Extracts of Glycyrrhiza uralensis Fischer
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Yoon Mi-Young
Jeon Kyung-Im
Son Eun-Soon
Kim Ji-Hyun
Kim Yong-Sung
Park Eun-Ju
Park Hae-Ryong
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Abstract
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In the present study, we investigated the glutathione S-transferase (GST) induction of medicinal plants using a cultured PC12 cells. The methanol extracts of Dendrobium nobile Lindley, Schizonepeta tenuifolia Briquet, Glycyrrhiza uralensis Fischer, Paenoia lactiflora Pall were tested. As the result, exposure of PC12 cells to G. uralensis resulted in the significant induction of GST. On the continuous experiment, G. uralensis was extracted with methanol, ethanol, and acetone. Among these extracts, methanol extracts showed the highest GST induction. The methanol extracts were further fractionated with hexane, diethyl ether, ethyl acetate, and water layer according to the degree of polarity. The diethyl ether layer showed the highest exhibited GST induction on PC12 cells. Based on these results suggest that the extracts of G. uralensis can be applicable for the development of a new antioxidant agent.
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KEYWORD
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G. uralensis Fischer, glutathione S-transferase, medicinal plants, PC12 cells
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